Comparison · Longevity
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Compare up to 4 peptides from the Longevity category. Tick any two or more — mechanism, protocols, side effects, stacking partners, and best $/mg update instantly.
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Tick any 2–4 peptides from this category. The comparison updates instantly.
4 / 4 selected
- Biohackers curious about longevity and anti-aging
- Older adults struggling with sleep patterns
- Optimists interested in cutting-edge wellness trends
- People interested in cutting-edge longevity research
- Biohackers looking to explore cellular health
- Individuals curious about age-related wellness
- Those intrigued by mitochondrial function
- Fitness enthusiasts curious about the next big thing in energy management
- Older adults looking to support healthy aging
- Biohackers interested in cutting-edge longevity research
- Biohackers curious about cutting-edge longevity research
- Night owls seeking to balance their sleep cycles
- Individuals interested in age-related gene research
- Skeptics who prefer widely verified research
- Those wary of unapproved treatments
- People who avoid needles
- Anyone uncomfortable with experimental peptides
- Individuals looking for quick fixes or guaranteed results
- People who prefer well-established supplements
- People looking for a quick fix without lifestyle changes
- Those uncomfortable with the unknowns of emerging science
- Individuals who prefer well-established supplements with long-term safety data
- People looking for quick, proven anti-aging results
- Those uncomfortable with experimental compounds
- Individuals expecting clear, immediate effects
- Telomerase activity (preclinical)
- Circadian and pineal regulation
- Cellular senescence markers
- Cellular cytoprotection (preclinical)
- Metabolic and endothelial markers
- Age-associated decline
- AMPK activation and metabolic flexibility
- Exercise and mitochondrial capacity
- Age-associated metabolic decline
- Improved peptide stability (preclinical)
- Pineal-axis and circadian research
- Cellular longevity markers
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson as a short-peptide analog of the pineal polypeptide complex Epithalamin. Preclinical research suggests it upreg…
Humanin is a 24-amino-acid mitochondrial-derived peptide encoded within the 16S rRNA region of mitochondrial DNA, originally identified in brain samples from an Alzheimer's patient by Hashimoto and c…
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA, discovered by the Pinchas Cohen laboratory at USC. Research suggests it acts as a meta…
N-Acetyl Epitalon Amidate is a stabilized structural analog of Epithalon in which the N-terminus is acetylated and the C-terminus is amidated, modifications intended to resist exopeptidase degradatio…
- Injection-site irritation and transient erythema
- Mild drowsiness when administered in the evening (consistent with pineal-axis effects)
- Long-term human safety data outside Russian cohort studies is limited
- Injection-site irritation
- Transient fatigue reported anecdotally
- Long-term human safety data is not established
- Injection-site irritation
- Transient hypoglycemia-like symptoms if combined with fasting or heavy training
- Long-term human safety data is limited
- Injection-site reactions
- Mild drowsiness with evening administration
- Human safety data is more limited than even the parent Epithalon
- Pregnancy and lactation (no safety data)
- Active malignancy (theoretical concern given telomerase-related research findings)
- Pediatric use
- Pregnancy and lactation
- Active malignancy (theoretical concern due to anti-apoptotic activity)
- Concurrent immunosuppressive therapy
- Pregnancy and lactation
- Type 1 diabetes (caution due to glucose-handling effects)
- Concurrent high-dose hypoglycemic therapy without supervision
- Pregnancy and lactation
- Active malignancy
- Pediatric use
Think of it as
Think of it as a potential fountain of youth for your cells.Best for
- Biohackers curious about longevity and anti-aging
- Older adults struggling with sleep patterns
- Optimists interested in cutting-edge wellness trends
Probably not for you if…
- Skeptics who prefer widely verified research
- Those wary of unapproved treatments
- People who avoid needles
Key benefits
- Telomerase activity (preclinical)
- Circadian and pineal regulation
- Cellular senescence markers
Mechanism of action
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson as a short-peptide analog of the pineal polypeptide complex Epithalamin. Preclinical research suggests it upreg…
Typical protocol
Reported side effects
- Injection-site irritation and transient erythema
- Mild drowsiness when administered in the evening (consistent with pineal-axis effects)
- Long-term human safety data outside Russian cohort studies is limited
Contraindications
- Pregnancy and lactation (no safety data)
- Active malignancy (theoretical concern given telomerase-related research findings)
- Pediatric use
Stacks well with
Best $/mg
Think of it as
Think of it as your cells' personal bodyguard.Best for
- People interested in cutting-edge longevity research
- Biohackers looking to explore cellular health
- Individuals curious about age-related wellness
- Those intrigued by mitochondrial function
Probably not for you if…
- Anyone uncomfortable with experimental peptides
- Individuals looking for quick fixes or guaranteed results
- People who prefer well-established supplements
Key benefits
- Cellular cytoprotection (preclinical)
- Metabolic and endothelial markers
- Age-associated decline
Mechanism of action
Humanin is a 24-amino-acid mitochondrial-derived peptide encoded within the 16S rRNA region of mitochondrial DNA, originally identified in brain samples from an Alzheimer's patient by Hashimoto and c…
Typical protocol
Reported side effects
- Injection-site irritation
- Transient fatigue reported anecdotally
- Long-term human safety data is not established
Contraindications
- Pregnancy and lactation
- Active malignancy (theoretical concern due to anti-apoptotic activity)
- Concurrent immunosuppressive therapy
Best $/mg
Think of it as
Think of it as a personal trainer for your cells.Best for
- Fitness enthusiasts curious about the next big thing in energy management
- Older adults looking to support healthy aging
- Biohackers interested in cutting-edge longevity research
Probably not for you if…
- People looking for a quick fix without lifestyle changes
- Those uncomfortable with the unknowns of emerging science
- Individuals who prefer well-established supplements with long-term safety data
Key benefits
- AMPK activation and metabolic flexibility
- Exercise and mitochondrial capacity
- Age-associated metabolic decline
Mechanism of action
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA, discovered by the Pinchas Cohen laboratory at USC. Research suggests it acts as a meta…
Typical protocol
Reported side effects
- Injection-site irritation
- Transient hypoglycemia-like symptoms if combined with fasting or heavy training
- Long-term human safety data is limited
Contraindications
- Pregnancy and lactation
- Type 1 diabetes (caution due to glucose-handling effects)
- Concurrent high-dose hypoglycemic therapy without supervision
Stacks well with
Best $/mg
Think of it as
Think of it as a potential age-defying assistant.Best for
- Biohackers curious about cutting-edge longevity research
- Night owls seeking to balance their sleep cycles
- Individuals interested in age-related gene research
Probably not for you if…
- People looking for quick, proven anti-aging results
- Those uncomfortable with experimental compounds
- Individuals expecting clear, immediate effects
Key benefits
- Improved peptide stability (preclinical)
- Pineal-axis and circadian research
- Cellular longevity markers
Mechanism of action
N-Acetyl Epitalon Amidate is a stabilized structural analog of Epithalon in which the N-terminus is acetylated and the C-terminus is amidated, modifications intended to resist exopeptidase degradatio…
Typical protocol
Reported side effects
- Injection-site reactions
- Mild drowsiness with evening administration
- Human safety data is more limited than even the parent Epithalon
Contraindications
- Pregnancy and lactation
- Active malignancy
- Pediatric use
Best $/mg
For research purposes only. Not medical advice.