SIDE BY SIDE

Think of it as

Best for

• +People who often experience gut discomfort and are looking for new options to explore.
• +Those dealing with skin allergies or sensitivities seeking a soothing solution.
• +Biohackers interested in cutting-edge immune system support.

Probably not for you if…

• −Anyone expecting a quick fix for severe autoimmune conditions.
• −People who prefer traditional medicine approaches and are wary of new peptides.

Key benefits

• Gut inflammation research
• Mast-cell and allergic inflammation modulation
• Antimicrobial activity

Mechanism of action

KPV is a tripeptide (Lys-Pro-Val) corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). Preclinical research suggests it exerts anti-inflammatory activity in part …

Typical protocol

Reported side effects

• ·Generally well tolerated in preclinical work with no major adverse events reported
• ·Rare mild injection-site irritation reported anecdotally
• ·Transient flushing with higher subcutaneous doses

Contraindications

• !Pregnancy and lactation (no safety data)
• !Active melanoma (theoretical concern given structural relationship to α-MSH, although KPV lacks melanocortin receptor agonism at typical doses)
• !Known hypersensitivity to the peptide

Stacks well with

Best $/mg

Think of it as

Best for

• +Active individuals prone to cuts and scrapes
• +People interested in boosting their body's natural defenses
• +Those curious about immune system support
• +Individuals exploring skin healing solutions

Probably not for you if…

• −Anyone with a history of inflammatory skin conditions
• −Those with a known sensitivity to immune modulators
• −Individuals looking for a simple, one-size-fits-all solution

Key benefits

• Broad-spectrum antimicrobial research
• Wound-healing modulation
• Innate immune signaling

Mechanism of action

LL-37 is the 37-amino-acid C-terminal fragment of the human cathelicidin precursor hCAP-18 and the only cathelicidin encoded in the human genome. Research indicates broad-spectrum antimicrobial activ…

Typical protocol

Reported side effects

• ·Injection-site redness, itching, and mast-cell-driven flushing reported at higher doses
• ·Can be pro-inflammatory in certain contexts — dose and concentration matter
• ·Theoretical risk of exacerbating rosacea, psoriasis, or other cathelicidin-driven inflammatory skin conditions

Contraindications

• !Pregnancy and lactation (no safety data)
• !Active rosacea, psoriasis, or other conditions associated with elevated endogenous LL-37
• !Autoimmune disease with suspected cathelicidin involvement (e.g., SLE with anti-LL-37 antibodies)

Stacks well with

Best $/mg

Think of it as

Best for

• +People interested in cutting-edge immune system research.
• +Those curious about innovative ways to manage inflammation.
• +Individuals exploring new approaches to support respiratory health.

Probably not for you if…

• −Anyone seeking well-established, mainstream treatments.
• −People uncomfortable with experimental therapies.
• −Those who prefer solutions with extensive human trial data.

Key benefits

• Pulmonary inflammation research
• Immunomodulation and autoimmunity models
• Vascular and bronchial smooth-muscle modulation

Mechanism of action

VIP is a naturally-occurring 28-amino-acid neuropeptide that signals through VPAC1 and VPAC2 G-protein coupled receptors, raising intracellular cAMP. Research suggests it exerts broad anti-inflammato…

Typical protocol

Reported side effects

• ·Hypotension and flushing due to potent vasodilatory activity — particularly with IV delivery
• ·Diarrhea at higher doses (VIP is the secretagogue implicated in VIPoma)
• ·Headache and tachycardia reported in early clinical research

Contraindications

• !Pregnancy and lactation (no safety data)
• !Baseline hypotension or orthostatic intolerance
• !Active cardiovascular instability

Stacks well with

Best $/mg