VIP
Vasoactive Intestinal Peptide · Vasoactive Intestinal Polypeptide · Aviptadil (pharmaceutical analogue)
Think of it as a calming diplomat for your immune system.
VIP, or Vasoactive Intestinal Peptide, is like a peacekeeper for your body's immune response. It steps in to dial down the overactive parts of your immune system that might otherwise lead to inflammation and discomfort. This can be especially useful in situations where your body mistakenly attacks its own tissues, like in certain autoimmune conditions.
Besides calming inflammation, VIP also acts as a natural relaxant for your airways and blood vessels. Imagine it opening up the pathways in your lungs and improving circulation by widening blood vessels. This dual action might be why it's being looked at in research for lung-related issues and conditions involving high blood pressure in the lungs.
Most of the evidence comes from early studies or animal research, so we're still learning about its full potential. But the possibilities for helping with immune balance and respiratory health are intriguing.
Who it's for
- People interested in cutting-edge immune system research.
- Those curious about innovative ways to manage inflammation.
- Individuals exploring new approaches to support respiratory health.
Probably not for you if…
- Anyone seeking well-established, mainstream treatments.
- People uncomfortable with experimental therapies.
- Those who prefer solutions with extensive human trial data.
Editorial summary for research context · Not medical advice
Mechanism of Action
VIP is a naturally-occurring 28-amino-acid neuropeptide that signals through VPAC1 and VPAC2 G-protein coupled receptors, raising intracellular cAMP. Research suggests it exerts broad anti-inflammatory and immunomodulatory effects by downregulating Th1/Th17 responses, promoting regulatory T-cell phenotypes, suppressing TNF-α and IL-6, and modulating macrophage polarization toward an anti-inflammatory M2 state. It also has vasodilatory and bronchodilatory activity. Most human evidence is preclinical or from small clinical studies, including sarcoidosis and pulmonary arterial hypertension trials using inhaled or IV aviptadil.
Researched Benefits
Pulmonary inflammation research
Small open-label and early-phase studies of inhaled VIP/aviptadil have explored pulmonary sarcoidosis endpoints, with reductions in BAL cytokines reported.
- [Prasse et al. 2010]
Immunomodulation and autoimmunity models
Rodent models of rheumatoid arthritis, colitis, and multiple sclerosis show reduced disease severity and shifted cytokine profiles after VIP administration.
- [Delgado et al. 2001]
- [Gonzalez-Rey et al. 2006]
Vascular and bronchial smooth-muscle modulation
Potent endogenous vasodilator and bronchodilator; investigated in pulmonary arterial hypertension research via inhaled delivery.
- [Petkov et al. 2003]
Research Protocols
The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.
Inhaled research protocol
- Dosage
- 100 mcg
- Frequency
- four times daily
- Timing
- with meals and before bed
- Cycle
- 12 weeks
Published pulmonary-sarcoidosis research used inhaled delivery via nebulizer. Degradation is rapid so delivery format matters considerably.
Intranasal immune-focused research
- Dosage
- 50 mcg
- Frequency
- twice daily
- Timing
- morning and evening
- Cycle
- 8 weeks
Intranasal delivery has been used in research protocols focused on systemic immune modulation. VIP has a very short plasma half-life (~2 minutes) so frequent dosing is common.
Reported Side Effects
- Hypotension and flushing due to potent vasodilatory activity — particularly with IV delivery
- Diarrhea at higher doses (VIP is the secretagogue implicated in VIPoma)
- Headache and tachycardia reported in early clinical research
- Very short half-life limits systemic exposure but also necessitates frequent dosing
Contraindications
- Pregnancy and lactation (no safety data)
- Baseline hypotension or orthostatic intolerance
- Active cardiovascular instability
- Use of significant vasodilators or PDE5 inhibitors without physician oversight
- History of VIPoma or chronic secretory diarrhea
Stacking Partners
Peptides commonly paired with VIP in published research and protocol write-ups.
Vendor Pricing
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Gear + Companions
Reconstitution supplies and research-backed supplement companions for VIP. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.
Gear you'll need
· Reconstitution + storage essentialsBacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
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Research Papers
Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis
Prasse A, et al. · American Journal of Respiratory and Critical Care Medicine · 2010
PubMed 20019337 →Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions
Delgado M, Ganea D · Amino Acids · 2013
PubMed 21984404 →