LongevityResearch profile

Pinealon

EDR Peptide · Glu-Asp-Arg · Khavinson Tripeptide

Think of it as a brain's personal trainer.

Pinealon is like a personal trainer for your brain cells, helping them stay fit and resilient. Picture it as providing your neurons with a little extra support to handle stress, like an airbag for your brain during a bumpy cognitive ride.

This peptide seems to help brain cells survive and thrive, even when they're under pressure. In animal studies, Pinealon has shown potential in boosting memory and cognitive performance, especially in aging brains. It's suggested to work by tweaking how certain genes in the brain express themselves, possibly enhancing brain plasticity and reducing the signals that lead to cell death.

While most of the research comes from Russian studies, the idea is that Pinealon could offer some neuroprotective benefits, especially as we age. But remember, this is still largely an exploratory area of science, and human data outside of specific research groups is limited.

Who it's for

Older adults curious about brain health support
Biohackers interested in cognitive longevity
People exploring ways to enhance mental resilience

Probably not for you if…

Those looking for quick cognitive fixes
Individuals wary of limited human research
Anyone uncomfortable with exploratory science

Editorial summary for research context · Not medical advice

Mechanism of Action

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) from the Khavinson short-peptide bioregulator program, designed based on the amino acid composition of pineal polypeptide fractions. Research suggests effects on neuronal survival under oxidative and hypoxic stress, modulation of gene expression in CNS tissue, and support of cognitive markers in aged rodent models. Russian clinical and preclinical literature positions it as a cognitive- and neuroprotective-oriented bioregulator. Human data outside the Khavinson group is very limited.

Researched Benefits

Neuroprotection under oxidative stress (preclinical)

Rodent and in vitro models of hypoxia and oxidative challenge report improved neuronal survival and reduced apoptosis markers.

[Khavinson et al. 2011]
[Arutjunyan et al. 2012]

Cognitive markers in aging

Aged rodent cognitive assays report improved performance in maze-based memory tasks versus control. Research suggests mechanisms involving modulation of CNS gene expression.

[Kolchina et al. 2012]

CNS gene expression modulation

Preclinical research suggests upregulation of genes involved in neuronal plasticity and downregulation of pro-apoptotic signaling in aged CNS tissue.

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

Standard Khavinson research cycle

Dosage: 10 mg
Frequency: once daily
Timing: morning
Cycle: 2 weeks

Russian research protocols typically use 10-20 consecutive days of subcutaneous administration, 1-2 times per year. Morning timing is common given cognitive orientation.

Low-dose research

Dosage: 5 mg
Frequency: every other day
Timing: morning
Cycle: 4 weeks

Alternate-day lower-dose protocol used in longer research observations.

Reported Side Effects

Injection-site irritation
Mild headache on initiation reported anecdotally
Long-term safety data outside Khavinson group publications is limited

Contraindications

Pregnancy and lactation
Active CNS malignancy
Pediatric use

Stacking Partners

Peptides commonly paired with Pinealon in published research and protocol write-ups.

longevity

Vendor Pricing

75
Swiss Chems
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/ mg$2.90/mg
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65
SolXGenix
Size20mg
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/ mg$3.00/mg
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75
LA Peptides
Size20mg
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/ mg$3.00/mg
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73
Platinum Lion Peptides
Size20mg
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/ mg$3.25/mg
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74
Purity Peptides
Size20mg
Total$71.99
/ mg$3.60/mg
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67
True Peptide Labs
Size10mg
Total$45.00
/ mg$4.50/mg
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74
Modern Research Peptides
Size10mg
Total$46.99
/ mg$4.70/mg
In stock
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70
Certified Peptides
Size20mg
Total$105.00
/ mg$5.25/mg
In stock
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Research Papers

Neuroprotective effects of tripeptides on brain neurons under oxidative stress
Arutjunyan A, Kozina L, Milyutina Y, Korenevsky A, et al. · Bulletin of Experimental Biology and Medicine · 2012
Peptidergic regulation of cell aging and gene expression
Khavinson VKh, Kuznik BI, Ryzhak GA · Advances in Gerontology · 2012

Pinealon

Mechanism of Action

Researched Benefits