LongevityResearch profile

N-Acetyl Epitalon Amidate

N-Acetyl Epithalon · Ac-Epitalon · Ac-Ala-Glu-Asp-Gly-NH2 · NAE

Think of it as a potential age-defying assistant.

N-Acetyl Epitalon Amidate is like an upgraded version of a peptide called Epithalon, designed to stick around longer in your body. Scientists think it might play a role in tweaking genes related to aging, much like its predecessor, but with a bit more staying power.

Research suggests it could help regulate your body's natural rhythms, like sleep cycles, by interacting with your pineal gland—the same gland responsible for producing melatonin, the sleep hormone. This could mean a more stable internal clock as you age.

While it's mostly been studied in labs and on animals, the hope is that it might one day be part of a toolkit for those looking to support cellular health and longevity, though evidence in humans is still in the early stages.

Who it's for

Biohackers curious about cutting-edge longevity research
Night owls seeking to balance their sleep cycles
Individuals interested in age-related gene research

Probably not for you if…

People looking for quick, proven anti-aging results
Those uncomfortable with experimental compounds
Individuals expecting clear, immediate effects

Editorial summary for research context · Not medical advice

Mechanism of Action

N-Acetyl Epitalon Amidate is a stabilized structural analog of Epithalon in which the N-terminus is acetylated and the C-terminus is amidated, modifications intended to resist exopeptidase degradation and extend plasma half-life relative to the parent peptide. Proposed mechanism mirrors Epithalon: modulation of hTERT expression, pineal-axis gene regulation, and chromatin-level effects suggested by the Khavinson short-peptide bioregulator framework. Comparative pharmacokinetic data versus Epithalon in humans is sparse; most claims are extrapolated from in vitro stability assays and rodent dosing studies.

Researched Benefits

Improved peptide stability (preclinical)

In vitro assays suggest increased resistance to plasma peptidases versus unmodified Epithalon, potentially allowing lower or less frequent dosing in research models.

Pineal-axis and circadian research

Research has explored similar endpoints to Epithalon: melatonin rhythm normalization and age-associated gene expression modulation.

[Khavinson et al. 2014]

Cellular longevity markers

Preclinical models suggest effects on senescence-associated markers consistent with the broader Khavinson short-peptide family.

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

Research protocol

Dosage: 5 mg
Frequency: once daily
Timing: evening
Cycle: 3 weeks

Research cycles often mirror Epithalon dosing but at reduced totals given improved stability. Subcutaneous administration in published protocols.

Extended pulsed research

Dosage: 3 mg
Frequency: every other day
Timing: evening
Cycle: 6 weeks

Alternate-day dosing has been explored to leverage the extended half-life suggested by stability assays.

Reported Side Effects

Injection-site reactions
Mild drowsiness with evening administration
Human safety data is more limited than even the parent Epithalon

Contraindications

Pregnancy and lactation
Active malignancy
Pediatric use

Stacking Partners

Peptides commonly paired with N-Acetyl Epitalon Amidate in published research and protocol write-ups.

longevity

Vendor Pricing

65
SolXGenix
Size5mg
Total$58.00
/ mg$11.60/mg
Out of stock
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Gear + Companions

Reconstitution supplies and research-backed supplement companions for N-Acetyl Epitalon Amidate. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials

Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
View at Pantheon →
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Buy on Amazon →
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
Buy on Amazon →
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
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Stacks well with

· Supplement companions — independent evidence, not sponsored

NMN (Nicotinamide Mononucleotide) 500mg × 60 caps
Double Wood
Oral NAD+ precursor — cheaper daily stack-mate for injectable NAD+ and natural fit alongside Epithalon + MOTS-c longevity protocols.
Buy on Amazon →
Trans-Resveratrol 500mg (120 capsules)
Double Wood
Sirtuin-activating polyphenol — SIRT1 needs NAD+ as its cofactor. Classic NAD+/sirtuin stack.
Buy on Amazon →

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Research Papers

Short Peptides and Telomere Length Regulator Hormone Irisin: Relationship and Aging
Khavinson VKh, Popovich IG, Linkova NS · Bulletin of Experimental Biology and Medicine · 2020
PubMed 32388775 →
Peptides and Aging: Review of Research on Khavinson Short Peptides
Khavinson VKh, Linkova NS, Tarnovskaya SI · Advances in Gerontology · 2016

N-Acetyl Epitalon Amidate

Mechanism of Action