Selank
TP-7 · Thr-Lys-Pro-Arg-Pro-Gly-Pro
Think of it as a mental chill pill without the fog.
Selank is like a brain tune-up tool that helps keep your mind steady and focused. Imagine it as a calming whisper to your brain, easing anxiety without making you sleepy or sluggish. Unlike some common anti-anxiety meds that can leave you feeling like a zombie, Selank helps you stay sharp and alert.
This peptide seems to work by interacting with the brain's natural calming and mood-regulating systems. It encourages your brain to keep its cool, like a good friend reminding you to take a deep breath during stressful moments. Some studies, mostly out of Russia, suggest that Selank might also help with focus and attention, particularly when you're feeling anxious. But remember, it's not a magic bullet and isn't approved everywhere, including the U.S.
Who it's for
- Stressed-out professionals needing a non-drowsy calm
- Students looking for focus during exam season
- Meditation enthusiasts wanting a little extra zen
- Anyone seeking a gentle mood booster without heavy meds
Probably not for you if…
- People looking for a sedative or sleep aid
- Those wanting a quick-fix for severe anxiety
- Individuals who prefer FDA-approved treatments
Editorial summary for research context · Not medical advice
Mechanism of Action
Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, with a Pro-Gly-Pro stabilizing tail. Research suggests it modulates GABAergic and serotonergic transmission, influences enkephalin degradation, and alters expression of genes tied to monoaminergic signaling, producing anxiolytic-like effects in animal models without the sedation or dependence profile associated with benzodiazepines. It is registered in Russia as an anxiolytic but is not FDA-approved.
Researched Benefits
Anxiolytic research
Rodent elevated-plus-maze and open-field studies have shown anxiolytic-like behavior comparable to diazepam without motor impairment.
- [Kozlovskaya et al. 2003]
Enkephalinase inhibition
Preclinical data suggest Selank slows breakdown of endogenous enkephalins, extending their signaling window.
- [Zozulia et al. 2008]
Cognition and attention endpoints
Russian clinical literature has explored Selank in generalized-anxiety cohorts with attention task outcomes.
- [Medvedev et al. 2007]
Research Protocols
The following dosing ranges have appeared in published research protocols. Presented for informational purposes only, not a recommendation for human use.
Intranasal anxiolytic research
- Dosage
- 900 mcg
- Frequency
- 2-3x daily
- Timing
- spread across the day
- Cycle
- 2 weeks
Russian 0.15% nasal solutions commonly deliver ~75 mcg per drop; research protocols have used 2-3 drops per nostril, 2-3 times daily, for 10-14 days.
Reported Side Effects
- Nasal irritation or dryness
- Mild drowsiness or light-headedness at higher doses
- Headache reported in a minority of users
- Rare gastrointestinal upset
Contraindications
- Pregnancy and lactation
- Concurrent benzodiazepine or other CNS-depressant therapy without medical supervision
- Known hypersensitivity to tuftsin-family peptides
Stacking Partners
Peptides commonly paired with Selank in published research and protocol write-ups.
Vendor Pricing
Stacked earns a commission on purchases via these links. It does not influence our Trust Scores.
Gear + Companions
Reconstitution supplies and research-backed supplement companions for Selank. Editorial picks only, we earn a commission through Amazon on the click, no sponsorship.
Gear you'll need
· Reconstitution + storage essentialsBacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Stacks well with
· Supplement companions, independent evidence, not sponsoredAlpha-GPC 600mg (60 capsules)
Double Wood
Choline donor — upregulates acetylcholine synthesis. Cognitive peptides that boost neurotransmitter signaling still need the substrate.
Lion's Mane Mushroom Extract (120 capsules, 2g/serving)
Host Defense / Paul Stamets
Hericium erinaceus has direct NGF + BDNF evidence. Thematic stack-mate for any neuroprotective or neurogenesis peptide protocol.
Omega-3 Fish Oil (Molecularly Distilled, 240 softgels)
Nordic Naturals
DHA is the structural fat of neural membranes — cognitive peptide protocols benefit from optimized membrane lipids.
As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines
Top Videos
Curated from YouTube, refreshed weekly. Stacked doesn't host or endorse external content.
10:29The Truth About Selank: Unveiling Its Nootropic Potential
The Anxious Resistance
52K views · 10:29 · 2 years ago
9:57How Long For Selank To Work
Regan Archibald
28.4K views · 9:57 · 9 months ago
4:34I Tried Selank And It Was NOT What I Expected!
TheNootropicReviewer
20K views · 4:34 · 1 year ago
5:49SEMAX and SELANK: Exploring the Cognitive Potential of Nootropic Peptides
Peptide Buddy
13.8K views · 5:49 · 2 years ago
4:26Selank Peptide Review My Personal Experience
Wellness Centered
6.6K views · 4:26 · 1 year ago
Research Papers
Selank and its derivatives: biological activity and molecular mechanisms
Kozlovskaya MM, et al. · Experimental and Clinical Pharmacology · 2003
Efficacy of Selank in generalized anxiety disorder and neurasthenia
Medvedev VE, et al. · Zhurnal Nevrologii i Psikhiatrii · 2007
Frequently Asked
- What is Selank?
- Selank is a cognitive studied in laboratory research. This profile covers its researched mechanism of action, study context, reported side-effect profile, and current vendor pricing. For research purposes only; not medical advice.
- Is Selank legal to buy?
- Selank is sold strictly for laboratory and research use and is not approved by the FDA for human consumption. Legal status and import rules vary by country and are the buyer's responsibility.
- How much does Selank cost?
- Compare live $/mg, total price, stock, and each vendor's Stacked Score for Selank on its price page. Stacked does not sell peptides; it links out to vetted research vendors.





