Stacked
CognitiveResearch profile

Selank

TP-7 · Thr-Lys-Pro-Arg-Pro-Gly-Pro

Think of it as a mental chill pill without the fog.

Selank is like a brain tune-up tool that helps keep your mind steady and focused. Imagine it as a calming whisper to your brain, easing anxiety without making you sleepy or sluggish. Unlike some common anti-anxiety meds that can leave you feeling like a zombie, Selank helps you stay sharp and alert.

This peptide seems to work by interacting with the brain's natural calming and mood-regulating systems. It encourages your brain to keep its cool, like a good friend reminding you to take a deep breath during stressful moments. Some studies, mostly out of Russia, suggest that Selank might also help with focus and attention, particularly when you're feeling anxious. But remember, it's not a magic bullet and isn't approved everywhere, including the U.S.

Who it's for

  • Stressed-out professionals needing a non-drowsy calm
  • Students looking for focus during exam season
  • Meditation enthusiasts wanting a little extra zen
  • Anyone seeking a gentle mood booster without heavy meds

Probably not for you if…

  • People looking for a sedative or sleep aid
  • Those wanting a quick-fix for severe anxiety
  • Individuals who prefer FDA-approved treatments

Editorial summary for research context · Not medical advice

Mechanism of Action

Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, with a Pro-Gly-Pro stabilizing tail. Research suggests it modulates GABAergic and serotonergic transmission, influences enkephalin degradation, and alters expression of genes tied to monoaminergic signaling, producing anxiolytic-like effects in animal models without the sedation or dependence profile associated with benzodiazepines. It is registered in Russia as an anxiolytic but is not FDA-approved.

Researched Benefits

Anxiolytic research

Rodent elevated-plus-maze and open-field studies have shown anxiolytic-like behavior comparable to diazepam without motor impairment.

  • [Kozlovskaya et al. 2003]

Enkephalinase inhibition

Preclinical data suggest Selank slows breakdown of endogenous enkephalins, extending their signaling window.

  • [Zozulia et al. 2008]

Cognition and attention endpoints

Russian clinical literature has explored Selank in generalized-anxiety cohorts with attention task outcomes.

  • [Medvedev et al. 2007]

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only, not a recommendation for human use.

Intranasal anxiolytic research

Dosage
900 mcg
Frequency
2-3x daily
Timing
spread across the day
Cycle
2 weeks

Russian 0.15% nasal solutions commonly deliver ~75 mcg per drop; research protocols have used 2-3 drops per nostril, 2-3 times daily, for 10-14 days.

Reported Side Effects

  • Nasal irritation or dryness
  • Mild drowsiness or light-headedness at higher doses
  • Headache reported in a minority of users
  • Rare gastrointestinal upset

Contraindications

  • Pregnancy and lactation
  • Concurrent benzodiazepine or other CNS-depressant therapy without medical supervision
  • Known hypersensitivity to tuftsin-family peptides

Stacking Partners

Peptides commonly paired with Selank in published research and protocol write-ups.

Vendor Pricing

Stacked earns a commission on purchases via these links. It does not influence our Trust Scores.

Gear + Companions

Reconstitution supplies and research-backed supplement companions for Selank. Editorial picks only, we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials
  • Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)

    Empower Pharmacy / generic medical supply

    Reconstitutes every lyophilized peptide. 28-day viability refrigerated.

  • Insulin Syringes 31G × 5/16" × 0.5mL (100 count)

    EasyTouch

    31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.

  • Alcohol Prep Pads (Sterile, 200 count)

    Dynarex

    Sterile 70% IPA prep pads — one per vial stopper + one per injection site.

  • 1-Quart Sharps Disposal Container

    BD / Becton Dickinson

    FDA-cleared sharps container — pharmacies won't accept improvised disposal.

Stacks well with

· Supplement companions, independent evidence, not sponsored
  • Alpha-GPC 600mg (60 capsules)

    Double Wood

    Choline donor — upregulates acetylcholine synthesis. Cognitive peptides that boost neurotransmitter signaling still need the substrate.

  • Lion's Mane Mushroom Extract (120 capsules, 2g/serving)

    Host Defense / Paul Stamets

    Hericium erinaceus has direct NGF + BDNF evidence. Thematic stack-mate for any neuroprotective or neurogenesis peptide protocol.

  • Omega-3 Fish Oil (Molecularly Distilled, 240 softgels)

    Nordic Naturals

    DHA is the structural fat of neural membranes — cognitive peptide protocols benefit from optimized membrane lipids.

As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines

Top Videos

Curated from YouTube, refreshed weekly. Stacked doesn't host or endorse external content.

Research Papers

  • Selank and its derivatives: biological activity and molecular mechanisms

    Kozlovskaya MM, et al. · Experimental and Clinical Pharmacology · 2003

  • Efficacy of Selank in generalized anxiety disorder and neurasthenia

    Medvedev VE, et al. · Zhurnal Nevrologii i Psikhiatrii · 2007

Legal

For research purposes only. Not medical advice. Content on this page summarizes published preclinical and clinical research. It is not a recommendation for human use, nor a substitute for guidance from a qualified medical professional. Stacked does not sell peptides.

Summaries partially AI-assisted · citations verified against source material

Frequently Asked

What is Selank?
Selank is a cognitive studied in laboratory research. This profile covers its researched mechanism of action, study context, reported side-effect profile, and current vendor pricing. For research purposes only; not medical advice.
Is Selank legal to buy?
Selank is sold strictly for laboratory and research use and is not approved by the FDA for human consumption. Legal status and import rules vary by country and are the buyer's responsibility.
How much does Selank cost?
Compare live $/mg, total price, stock, and each vendor's Stacked Score for Selank on its price page. Stacked does not sell peptides; it links out to vetted research vendors.

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Details