Selank
TP-7 · Thr-Lys-Pro-Arg-Pro-Gly-Pro
Think of it as a mental chill pill without the fog.
Selank is like a brain tune-up tool that helps keep your mind steady and focused. Imagine it as a calming whisper to your brain, easing anxiety without making you sleepy or sluggish. Unlike some common anti-anxiety meds that can leave you feeling like a zombie, Selank helps you stay sharp and alert.
This peptide seems to work by interacting with the brain's natural calming and mood-regulating systems. It encourages your brain to keep its cool, like a good friend reminding you to take a deep breath during stressful moments. Some studies, mostly out of Russia, suggest that Selank might also help with focus and attention, particularly when you're feeling anxious. But remember, it's not a magic bullet and isn't approved everywhere, including the U.S.
Who it's for
- Stressed-out professionals needing a non-drowsy calm
- Students looking for focus during exam season
- Meditation enthusiasts wanting a little extra zen
- Anyone seeking a gentle mood booster without heavy meds
Probably not for you if…
- People looking for a sedative or sleep aid
- Those wanting a quick-fix for severe anxiety
- Individuals who prefer FDA-approved treatments
Editorial summary for research context · Not medical advice
Mechanism of Action
Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, with a Pro-Gly-Pro stabilizing tail. Research suggests it modulates GABAergic and serotonergic transmission, influences enkephalin degradation, and alters expression of genes tied to monoaminergic signaling, producing anxiolytic-like effects in animal models without the sedation or dependence profile associated with benzodiazepines. It is registered in Russia as an anxiolytic but is not FDA-approved.
Researched Benefits
Anxiolytic research
Rodent elevated-plus-maze and open-field studies have shown anxiolytic-like behavior comparable to diazepam without motor impairment.
- [Kozlovskaya et al. 2003]
Enkephalinase inhibition
Preclinical data suggest Selank slows breakdown of endogenous enkephalins, extending their signaling window.
- [Zozulia et al. 2008]
Cognition and attention endpoints
Russian clinical literature has explored Selank in generalized-anxiety cohorts with attention task outcomes.
- [Medvedev et al. 2007]
Research Protocols
The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.
Intranasal anxiolytic research
- Dosage
- 900 mcg
- Frequency
- 2-3x daily
- Timing
- spread across the day
- Cycle
- 2 weeks
Russian 0.15% nasal solutions commonly deliver ~75 mcg per drop; research protocols have used 2-3 drops per nostril, 2-3 times daily, for 10-14 days.
Reported Side Effects
- Nasal irritation or dryness
- Mild drowsiness or light-headedness at higher doses
- Headache reported in a minority of users
- Rare gastrointestinal upset
Contraindications
- Pregnancy and lactation
- Concurrent benzodiazepine or other CNS-depressant therapy without medical supervision
- Known hypersensitivity to tuftsin-family peptides
Stacking Partners
Peptides commonly paired with Selank in published research and protocol write-ups.
Vendor Pricing
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Gear + Companions
Reconstitution supplies and research-backed supplement companions for Selank. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.
Gear you'll need
· Reconstitution + storage essentialsBacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Stacks well with
· Supplement companions — independent evidence, not sponsoredAlpha-GPC 600mg (60 capsules)
Double Wood
Choline donor — upregulates acetylcholine synthesis. Cognitive peptides that boost neurotransmitter signaling still need the substrate.
Lion's Mane Mushroom Extract (120 capsules, 2g/serving)
Host Defense / Paul Stamets
Hericium erinaceus has direct NGF + BDNF evidence. Thematic stack-mate for any neuroprotective or neurogenesis peptide protocol.
Omega-3 Fish Oil (Molecularly Distilled, 240 softgels)
Nordic Naturals
DHA is the structural fat of neural membranes — cognitive peptide protocols benefit from optimized membrane lipids.
As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines
Top Videos
Curated from YouTube — refreshed weekly. Stacked doesn't host or endorse external content.
10:29The Truth About Selank: Unveiling Its Nootropic Potential
The Anxious Resistance
42.7K views · 10:29 · 2 years ago
6:46I Tried 2 Peptide Nootropics for 60 Days — Here’s What Happened
Michael Morelli
16.4K views · 6:46 · 8 months ago
9:57How Long For Selank To Work
Regan Archibald
15.5K views · 9:57 · 6 months ago
8:32Intranasal vs Injection: Which Semax and Selank Method Works Better
David DeMesquita
15.3K views · 8:32 · 2 months ago
4:34I Tried Selank And It Was NOT What I Expected!
TheNootropicReviewer
15K views · 4:34 · 1 year ago
Research Papers
Selank and its derivatives: biological activity and molecular mechanisms
Kozlovskaya MM, et al. · Experimental and Clinical Pharmacology · 2003
Efficacy of Selank in generalized anxiety disorder and neurasthenia
Medvedev VE, et al. · Zhurnal Nevrologii i Psikhiatrii · 2007