OtherResearch profile

5-Amino-1MQ

5-Amino-1-Methylquinolinium · NNMT inhibitor

Think of it as a potential metabolic tune-up.

5-Amino-1MQ is like a mechanic for your body's metabolism, especially when it comes to fat cells. In preclinical studies, this compound has shown promise in shrinking fat cells, which might help with weight control. It's thought to do this by blocking an enzyme that usually slows down energy expenditure. Imagine turning up the dial on your body's energy burn.

Another interesting aspect is its potential to boost NAD levels, which are crucial for cellular energy and repair processes. Higher NAD levels can support different bodily functions, like muscle maintenance, which is particularly intriguing for aging populations. This compound is still in the research phase, so while it shows promise in lab settings, its full effects on humans aren't yet known.

Who it's for

Biohackers interested in metabolism optimization
Aging individuals curious about muscle maintenance
Fitness enthusiasts looking for cutting-edge research

Probably not for you if…

Those looking for well-established weight loss solutions
Individuals uncomfortable with experimental compounds
Anyone expecting immediate or guaranteed results

Editorial summary for research context · Not medical advice

Mechanism of Action

5-Amino-1MQ is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue of obese individuals. NNMT consumes SAM and NAD-precursor methyl donors to produce 1-methylnicotinamide, and elevated NNMT activity is associated with reduced adipocyte energy expenditure and impaired NAD/methylation pools. Inhibition of NNMT in preclinical models shrinks adipocytes, increases cellular NAD, and restores methyl-donor availability. It is a research-grade small molecule, not a peptide, and has no approved human indication.

Researched Benefits

Adipocyte size reduction (preclinical)

Diet-induced obesity mouse models reported ~7% reduction in body weight and significantly smaller white adipocytes after ~11 days of treatment versus vehicle.

[Neelakantan et al. 2018]

NAD and methyl-donor restoration

NNMT inhibition in preclinical models raises cellular NAD+ and SAM levels, supporting sirtuin activity and epigenetic methylation capacity.

[Kraus et al. 2014]

Muscle quality in aged models

Aged murine studies have explored NNMT inhibition for reversing sarcopenia markers and improving muscle stem-cell function.

[Neelakantan et al. 2019]

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

Preclinical research reference

Dosage: 5 mg
Frequency: once daily
Timing: morning
Cycle: 8 weeks

Rodent studies have used ~20 mg/kg oral dosing. No validated human pharmacokinetic data and no approved formulation. Research use only.

Reported Side Effects

Human safety data is extremely limited — no completed clinical trials
Unknown long-term effects on systemic methylation and NAD metabolism
Gastrointestinal discomfort reported anecdotally with oral use
Potential for off-target methyltransferase interactions at high doses

Contraindications

Pregnancy and lactation (no safety data)
Active malignancy (NAD/methylation pathways are broadly implicated in cancer biology)
Concurrent methylation-sensitive medications without clinical oversight

Stacking Partners

Peptides commonly paired with 5-Amino-1MQ in published research and protocol write-ups.

longevity

Vendor Pricing

75
LA Peptides
Best $/mg
Size50mg
Total$55.99
/ mg$1.12/mg
In stock
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74
Modern Research Peptides
Size50mg
Total$58.65
/ mg$1.17/mg
In stock
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73
Platinum Lion Peptides
Size50mg
Total$69.99
/ mg$1.40/mg
In stock
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72
Limitless Biotech
Size100mg
Total$157.29
/ mg$1.57/mg
In stock
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73
Royal Peptides
Size50mg
Total$90.00
/ mg$1.80/mg
In stock
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74
Modern Research Peptides
Size30mg
Total$59.99
/ mg$2.00/mg
In stock
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72
Southern Aminos
Size20mg
Total$44.25
/ mg$2.21/mg
In stock
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65
SolXGenix
Size50mg
Total$120.00
/ mg$2.40/mg
In stock
View

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Gear + Companions

Reconstitution supplies and research-backed supplement companions for 5-Amino-1MQ. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials

Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
View at Pantheon →
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Buy on Amazon →
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
Buy on Amazon →
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Buy on Amazon →

Stacks well with

· Supplement companions — independent evidence, not sponsored

NMN (Nicotinamide Mononucleotide) 500mg × 60 caps
Double Wood
Oral NAD+ precursor — cheaper daily stack-mate for injectable NAD+ and natural fit alongside Epithalon + MOTS-c longevity protocols.
Buy on Amazon →
Trans-Resveratrol 500mg (120 capsules)
Double Wood
Sirtuin-activating polyphenol — SIRT1 needs NAD+ as its cofactor. Classic NAD+/sirtuin stack.
Buy on Amazon →

As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines

Research Papers

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Neelakantan H, et al. · Biochemical Pharmacology · 2018
PubMed 29408488 →
Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase
Neelakantan H, et al. · Journal of Medicinal Chemistry · 2017
PubMed 28850227 →

5-Amino-1MQ

Mechanism of Action