SLU-PP-332
pan-ERR agonist · ERRα/β/γ agonist · exercise mimetic
Mechanism of Action
SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ), developed by Thomas Burris's group at Saint Louis University. ERRs are orphan nuclear receptors that drive transcription of mitochondrial biogenesis, fatty-acid oxidation, and oxidative-phosphorylation genes, the same programs activated by endurance exercise. In preclinical models the compound induces an exercise-mimetic gene-expression signature in skeletal muscle and reduces adiposity in diet-induced obese mice. It is a research-grade small molecule, not a peptide, with no completed human trials and no approved clinical indication.
Researched Benefits
Exercise-mimetic gene signature (preclinical)
In murine skeletal muscle, SLU-PP-332 induced transcriptional programs that overlap with endurance training, upregulating mitochondrial biogenesis, fatty-acid oxidation, and OXPHOS genes, without requiring physical activity.
- [Billon et al. 2023 (Nature Metabolism)]
Improved running endurance in mice
Treated mice ran longer distances on a treadmill versus vehicle controls, an effect attributed to enhanced muscle oxidative capacity rather than a stimulant action.
- [Billon et al. 2023]
Reduced adiposity in diet-induced obesity models
DIO mice on chronic SLU-PP-332 dosing showed lower fat mass and improved glucose tolerance compared to vehicle, consistent with elevated whole-body energy expenditure.
- [Billon et al. 2023]
Research Protocols
The following dosing ranges have appeared in published research protocols. Presented for informational purposes only, not a recommendation for human use.
Preclinical research reference
- Dosage
- 50 mg
- Frequency
- twice daily
- Timing
- morning and evening
- Cycle
- 4 weeks
Murine studies have used ~50 mg/kg intraperitoneal dosing twice daily. No validated human pharmacokinetic data, no oral bioavailability data in humans, and no approved formulation. Research use only.
Reported Side Effects
- No human safety data, no completed clinical trials
- ERR agonism affects multiple tissues (liver, muscle, brown adipose, heart, brain), long-term effects on cardiac and hepatic gene programs in humans are unknown
- Anecdotal reports include transient fatigue and GI discomfort with experimental use
- Potential interaction with thyroid-hormone signaling pathways (preclinical observation)
Contraindications
- Pregnancy and lactation (no safety data)
- Active malignancy, ERRα is implicated in certain cancer biology
- Cardiac arrhythmias or structural heart disease (ERRs influence cardiac gene programs)
- Concurrent use with other mitochondrial-modulating compounds without research oversight
Stacking Partners
Peptides commonly paired with SLU-PP-332 in published research and protocol write-ups.
Vendor Pricing
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Top Videos
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Research Papers
A synthetic ERR agonist alleviates metabolic syndrome
Billon C, Sitaula S, Banerjee S, et al. · Journal of Pharmacology and Experimental Therapeutics · 2023
PubMed 37105701 →Synthetic ERRα/β/γ agonist induces an ERR exercise-mimetic gene-expression signature in skeletal muscle and reduces obesity in mice
Billon C, Schoepke E, Avdagic A, et al. · Nature Metabolism · 2024
PubMed 39134750 →
Frequently Asked
- What is SLU-PP-332?
- SLU-PP-332 is a other studied in laboratory research. This profile covers its researched mechanism of action, study context, reported side-effect profile, and current vendor pricing. For research purposes only; not medical advice.
- Is SLU-PP-332 legal to buy?
- SLU-PP-332 is sold strictly for laboratory and research use and is not approved by the FDA for human consumption. Legal status and import rules vary by country and are the buyer's responsibility.
- How much does SLU-PP-332 cost?
- Compare live $/mg, total price, stock, and each vendor's Stacked Score for SLU-PP-332 on its price page. Stacked does not sell peptides; it links out to vetted research vendors.