Ovagen
Glu-Asp-Leu · EDL · Hepatocyte bioregulator
Think of it as a tune-up for your liver cells.
Ovagen is a synthetic peptide that plays a supporting role for your liver. Imagine it as a helper that sneaks into liver cells and whispers instructions on how to better clean up and repair themselves. It's like giving your liver a gentle nudge to refresh and rejuvenate, especially when it's feeling a bit sluggish.
Research from the Khavinson group suggests that Ovagen can encourage liver cells to grow and regenerate, potentially making your liver more efficient at its job. While the data is mostly from lab settings and some studies in older animals, it's an intriguing option for those curious about liver health.
Who it's for
- Health-conscious individuals curious about liver health.
- Biohackers interested in cellular rejuvenation.
- Middle-aged folks noticing changes in their body's recovery time.
Probably not for you if…
- Anyone expecting immediate, dramatic results.
- People looking for a solution with extensive human trials.
- Those uncomfortable with trying new, less-researched compounds.
Editorial summary for research context · Not medical advice
Mechanism of Action
Ovagen is a synthetic tripeptide (Glu-Asp-Leu) designed as a liver-tissue bioregulator focused on hepatocyte function. Khavinson-group research proposes that short peptides penetrate the cell membrane, enter the nucleus, and modulate tissue-specific gene expression — including markers relevant to hepatocyte regeneration and detoxification pathways. Not FDA-approved. Preclinical and limited clinical data from Khavinson group.
Researched Benefits
Hepatocyte regeneration research
Khavinson-lab cell-culture studies report modulation of gene expression relevant to hepatocyte proliferation markers.
- [Khavinson et al. 2014]
Preclinical hepatic-aging models
Russian-language studies have examined hepatic morphology and functional markers in aged rodents.
- [Chalisova et al. 2014]
Research Protocols
The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.
Intranasal research protocol
- Dosage
- 100 mcg
- Frequency
- once daily
- Timing
- morning
- Cycle
- 3 weeks
Khavinson-group protocols have typically used 20-30 day cycles.
Reported Side Effects
- No significant adverse events reported in published Khavinson-group studies
- Transient local irritation with intranasal administration
- Long-term human safety data limited
Contraindications
- Pregnancy and lactation (no safety data)
- Active hepatic malignancy (theoretical concern)
- Individual hypersensitivity to peptide components
Stacking Partners
Peptides commonly paired with Ovagen in published research and protocol write-ups.
Vendor Pricing
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Research Papers
Short peptides and hepatocyte gene expression
Khavinson VKh, et al. · Advances in Gerontology · 2014
Organotypic tissue culture responses to short peptides
Chalisova NI, et al. · Advances in Gerontology · 2014