OtherResearch profile

Kisspeptin-10

KP-10 · Metastin (45-54) · Kiss1 C-terminal decapeptide

Think of it as the body’s fertility traffic cop.

Kisspeptin-10 is like the conductor of an orchestra, orchestrating the complex symphony of hormones that regulate reproduction. This peptide sends signals to your brain to start the hormone cascade that eventually leads to the release of reproductive hormones. It's a bit like turning on the engine of a car—it doesn't drive the car itself but starts the whole process.

Researchers are looking at Kisspeptin-10 for its potential in fertility treatments and hormone testing. It's particularly interesting for its role in potentially triggering ovulation in a more controlled manner than traditional methods, which might mean fewer side effects for some people. Think of it as a more nuanced way to encourage the body's natural processes to kick in.

Who it's for

Couples exploring fertility treatments who are curious about new options
Health enthusiasts interested in understanding hormonal regulation
People keen on the latest research in reproductive health

Probably not for you if…

Those uninterested in fertility or hormone-related issues
Individuals looking for direct action on reproductive organs
Anyone expecting instant results without medical guidance

Editorial summary for research context · Not medical advice

Mechanism of Action

Kisspeptin-10 is the biologically active C-terminal decapeptide of kisspeptin (encoded by the KISS1 gene), signaling through the GPR54/KISS1R receptor. Research identifies kisspeptin as a master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis — it stimulates GnRH neurons in the hypothalamus, leading to pulsatile LH and, to a lesser extent, FSH release from the pituitary. Clinical research has explored kisspeptin-10 in diagnostic GnRH-axis testing and in fertility research protocols as a potential alternative to hCG-based trigger strategies. It does not directly act on the testes or ovaries; all downstream effects are mediated through endogenous GnRH, LH, and FSH.

Researched Benefits

LH pulse stimulation research

Bolus and infusion studies in healthy male and female volunteers demonstrate reproducible, physiological LH release via endogenous GnRH.

[Dhillo et al. 2005]
[Jayasena et al. 2014]

Ovulation-trigger research (fertility)

Clinical studies have explored single-dose kisspeptin-54 and KP-10 as an ovulation trigger in IVF cycles, with reduced OHSS rates versus hCG reported in some cohorts.

[Abbara et al. 2015]

HPG-axis diagnostic probe

Used experimentally to characterize hypothalamic vs pituitary dysfunction by comparing LH response to kisspeptin vs GnRH challenge.

[Chan et al. 2014]

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

HPG-axis research (subcutaneous bolus)

Dosage: 100 mcg
Frequency: every other day
Timing: morning
Cycle: 4 weeks

Research protocols have used subcutaneous bolus administration. KP-10 has a very short half-life (minutes), so single boluses produce a transient LH pulse rather than sustained stimulation.

Intranasal research

Dosage: 200 mcg
Frequency: daily
Timing: morning
Cycle: 4 weeks

Intranasal delivery has been investigated in HPG-axis research. Systemic bioavailability is lower than parenteral routes.

Reported Side Effects

Transient headache and flushing reported in clinical research
Mild injection-site reactions
Theoretical HPG-axis disruption with sustained non-physiological dosing
Potential for altered menstrual cyclicity in females
Long-term human safety data is limited

Contraindications

Pregnancy (kisspeptin is elevated physiologically in pregnancy; exogenous dosing is not studied and theoretically risky)
Active hormone-sensitive cancer (prostate, breast, ovarian, endometrial) — downstream LH/testosterone/estradiol elevation is theoretically concerning
Active fertility treatment without reproductive-endocrinology oversight — interaction with IVF protocols, trigger shots, and GnRH analogues is complex
Precocious puberty or pediatric use
Known hypersensitivity to the peptide

Stacking Partners

Peptides commonly paired with Kisspeptin-10 in published research and protocol write-ups.

other

Vendor Pricing

74
Modern Research Peptides
Best $/mg
Size10mg
Total$39.99
/ mg$4.00/mg
In stock
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67
True Peptide Labs
Size10mg
Total$40.00
/ mg$4.00/mg
In stock
View
73
Royal Peptides
Size100mg
Total$420.00
/ mg$4.20/mg
In stock
View
72
Southern Aminos
Size10mg
Total$48.75
/ mg$4.88/mg
In stock
View
73
Platinum Lion Peptides
Size10mg
Total$49.99
/ mg$5.00/mg
In stock
View
75
Ascension Peptides
Size10mg
Total$58.00
/ mg$5.80/mg
In stock
View
74
Purity Peptides
Size10mg
Total$64.79
/ mg$6.48/mg
In stock
View
65
SolXGenix
Size10mg
Total$75.00
/ mg$7.50/mg
In stock
View

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Gear + Companions

Reconstitution supplies and research-backed supplement companions for Kisspeptin-10. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials

Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
View at Pantheon →
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Buy on Amazon →
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
Buy on Amazon →
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Buy on Amazon →

Stacks well with

· Supplement companions — independent evidence, not sponsored

L-Citrulline Malate 1kg Unflavored Powder
BulkSupplements
Central + peripheral NO signaling stack — PT-141 works on the brain, L-citrulline on the vasculature.
Buy on Amazon →

As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines

Research Papers

Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males
Dhillo WS, et al. · Journal of Clinical Endocrinology & Metabolism · 2005
PubMed 16030164 →
Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization
Jayasena CN, et al. · Journal of Clinical Investigation · 2014
PubMed 25202976 →

Kisspeptin-10

Mechanism of Action