OtherResearch profile

HMG

Human Menopausal Gonadotropin · Menotropin · Menopur · Repronex

Think of it as a fertility booster pack.

HMG, or Human Menopausal Gonadotropin, is like a personal trainer for your reproductive system. It's extracted from the urine of post-menopausal women and contains hormones that help both women and men in the fertility department. In women, it encourages the ovaries to produce eggs, which is particularly useful during treatments like IVF. For men, it supports the production of sperm—essentially giving a helping hand to those looking to boost their chances of conception.

In assisted reproduction, HMG can often outperform other fertility treatments, especially when used in specific IVF protocols. It's a key player for those needing a little extra hormonal push to get the reproductive cycle running smoothly.

Who it's for

Couples undergoing IVF or other fertility treatments.
Men looking to improve sperm production.
Women needing hormonal support for egg production.

Probably not for you if…

People not pursuing fertility treatments.
Those who prefer non-hormonal interventions.
Individuals without a prescription or medical guidance.

Editorial summary for research context · Not medical advice

Mechanism of Action

HMG is a purified gonadotropin preparation extracted from the urine of post-menopausal women, containing approximately equal activity of FSH and LH (75 IU of each per vial in most formulations). FSH stimulates follicular recruitment and granulosa-cell proliferation in women, and Sertoli-cell activity and spermatogenesis in men. LH activity drives theca-cell androgen synthesis in women and Leydig-cell testosterone production in men. HMG is FDA-approved as Menopur and Repronex and is prescription-only; it is not a research chemical.

Researched Benefits

Controlled ovarian stimulation (IVF/IUI)

Randomized trials in assisted reproduction demonstrate comparable or superior clinical pregnancy rates versus recombinant FSH alone, particularly in long-protocol IVF cycles.

[Al-Inany et al. 2009]
[Coomarasamy et al. 2008]

Spermatogenesis induction in men with HH

In hypogonadotropic hypogonadism, combined HCG + HMG therapy restores spermatogenesis in the majority of previously azoospermic men over 6-24 months.

[Warne et al. 2009]
[Rastrelli et al. 2014]

LH-deficient cycle rescue

HMG provides LH activity in down-regulated IVF cycles where endogenous LH is suppressed and pure FSH alone may produce suboptimal steroidogenesis.

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

Ovarian stimulation (physician-directed)

Dosage: 150 IU
Frequency: once daily
Timing: subcutaneous or IM, evening
Cycle: 2 weeks

Typical IVF starting dose 150-225 IU/day, titrated by follicular ultrasound and estradiol monitoring; trigger with HCG or GnRH agonist when lead follicles reach ~18mm. Prescription-only, requires fertility specialist.

Spermatogenesis induction (physician-directed)

Dosage: 75 IU
Frequency: 3x weekly
Timing: subcutaneous or IM
Cycle: 24 weeks

Endocrinology protocols typically layer HMG 75-150 IU 3x weekly onto HCG 1500-3000 IU 2-3x weekly in hypogonadotropic men after 3-6 months of HCG monotherapy. Long courses (6-24 months) are required.

Reported Side Effects

Ovarian hyperstimulation syndrome (mild to severe)
Multiple pregnancy
Injection-site reactions
Abdominal bloating and pelvic discomfort
Headache
Breast tenderness
Thromboembolic events (rare)

Contraindications

Primary ovarian failure
Uncontrolled thyroid or adrenal dysfunction
Tumor of the pituitary or hypothalamus
Sex-hormone-dependent tumors
Abnormal uterine bleeding of undetermined origin
Pregnancy
Prior hypersensitivity to menotropin products

Stacking Partners

Peptides commonly paired with HMG in published research and protocol write-ups.

other

HCG

Testicular function preservation during TRT

other

Gonadorelin

HPTA support during androgen therapy

Vendor Pricing

75
Swiss Chems
Best $/mg
Size1mg
Total$37.95
/ mg$37.95/mg
In stock
View

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Gear + Companions

Reconstitution supplies and research-backed supplement companions for HMG. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials

Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
View at Pantheon →
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Buy on Amazon →
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
Buy on Amazon →
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Buy on Amazon →

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Research Papers

Efficacy and safety of human menopausal gonadotrophin versus recombinant FSH: a meta-analysis
Al-Inany HG, et al. · Reproductive BioMedicine Online · 2009
PubMed 19281667 →
Gonadotropin therapy in hypogonadotropic hypogonadism: long-term fertility outcome
Rastrelli G, et al. · Andrology · 2014
PubMed 24659643 →

HMG

Mechanism of Action