BioregulatorsResearch profile

Cortagen

Ala-Glu-Asp-Pro · AEDP · Brain cortex bioregulator

Think of it as a brain's personal trainer.

Cortagen is like a little pep talk for your brain. It's a synthetic compound designed to support brain health by influencing how certain genes are expressed in your cerebral cortex, which is the brain's thinking cap. Imagine it as a personal trainer for your neurons, encouraging them to grow, connect, and repair themselves.

Research, mostly from Russia, suggests that Cortagen might help with brain functions related to memory and learning, especially as we age. Some animal studies also hint that it could aid in nerve recovery after injuries. However, it's important to note that most of this research is still in the early stages and hasn't yet crossed over into mainstream human trials.

Who it's for

Biohackers interested in cognitive enhancement
Aging individuals curious about brain health support
Neuroscience enthusiasts who follow cutting-edge research

Probably not for you if…

Those expecting immediate, well-documented results
People looking for FDA-approved treatments
Anyone uncomfortable with experimental compounds

Editorial summary for research context · Not medical advice

Mechanism of Action

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) designed as a cerebral cortex bioregulator. Khavinson-group research proposes that short peptides of this class penetrate neuronal membranes and modulate gene expression involved in neuronal differentiation, synaptic plasticity, and cortical tissue repair. Preclinical work has examined traumatic brain injury and peripheral nerve regeneration models. Not FDA-approved. Preclinical and limited human data from Khavinson group.

Researched Benefits

Cortical gene-expression modulation

Khavinson-lab studies report modulation of gene expression relevant to neuronal differentiation and synaptic markers in cortical preparations.

[Khavinson et al. 2013]

Peripheral nerve regeneration research

Preclinical rodent studies have examined nerve conduction recovery following sciatic-nerve crush injury.

[Ryzhak et al. 2003]

Cognitive-aging preclinical models

Russian-language behavioral studies have examined memory and learning endpoints in aged rodents.

[Khavinson & Malinin 2005]

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

Intranasal research protocol

Dosage: 100 mcg
Frequency: once daily
Timing: morning
Cycle: 3 weeks

Khavinson-group protocols have typically used 20-30 day cycles.

Reported Side Effects

No significant adverse events reported in published Khavinson-group studies
Transient local irritation with intranasal administration
Long-term human safety data limited

Contraindications

Pregnancy and lactation (no safety data)
Active CNS malignancy (theoretical concern)
Individual hypersensitivity to peptide components

Stacking Partners

Peptides commonly paired with Cortagen in published research and protocol write-ups.

longevity

Vendor Pricing

75
Swiss Chems
Best $/mg
Size20mg
Total$46.95
/ mg$2.35/mg
In stock
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74
Purity Peptides
Size20mg
Total$79.19
/ mg$3.96/mg
In stock
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Research Papers

Gerontological aspects of peptide regulation
Khavinson VKh, Malinin VV · Karger · 2005
Regenerative effects of cortexin and cortagen in peripheral nerve injury models
Ryzhak GA, et al. · Advances in Gerontology · 2003

Cortagen

Mechanism of Action