PerformanceResearch profile

Adipotide

FTPP · Fat-targeted proapoptotic peptide · Prohibitin-TP01

Think of it as a targeted demolition crew for fat cells.

Adipotide is like a precision strike against fat tissue. It targets the blood vessels that feed your body's white fat, cutting off their supply and causing them to naturally break down. Imagine a building losing its plumbing—eventually, it can't function and falls apart. This approach has shown promise in animals and even in a small human study, leading to weight loss by essentially starving fat cells.

What's interesting about Adipotide is that it skips the usual route of making you feel full. Instead, it goes right to the source, focusing on the infrastructure that supports fat tissue. It's a different way to tackle weight loss, separate from those appetite-suppressing treatments you might have heard about.

Who it's for

People exploring new weight loss strategies beyond diet and exercise.
Biohackers interested in cutting-edge fat loss research.
Fitness enthusiasts curious about novel approaches to managing body composition.

Probably not for you if…

Anyone looking for FDA-approved weight loss treatments.
Individuals with existing kidney issues.
Those averse to experimental and early-stage research treatments.

Editorial summary for research context · Not medical advice

Mechanism of Action

Adipotide is an experimental peptidomimetic that couples a homing motif targeting prohibitin on white adipose tissue vasculature to a pro-apoptotic sequence (KLAKLAK). In preclinical research, binding triggers apoptosis of endothelial cells supplying white fat depots, leading to regression of adipose tissue and weight loss in obese rodents and non-human primates. A small Phase 1 trial in obese humans with prostate cancer showed weight loss but also signaled renal tubular toxicity. Adipotide remains at an early-stage, preclinical-to-limited-human-research stage and is not FDA-approved.

Researched Benefits

Adipose vasculature ablation (preclinical)

Rodent and primate studies show targeted apoptosis of white adipose vessels with substantial fat loss.

[Kolonin et al. 2004]
[Barnhart et al. 2011]

Weight loss in early human study

A Phase 1 trial in obese prostate cancer patients observed measurable weight and waist circumference reduction.

[Azad et al. 2015]

Mechanism distinct from GLP-1 agonists

Targets adipose vasculature directly rather than central appetite pathways, representing a different research approach.

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

Early-stage research reference

Dosage: 1 mg
Frequency: once daily
Timing: any time
Cycle: 4 weeks

Research has explored short SC cycles followed by extended washout; human dosing is poorly characterized and investigational only.

Reported Side Effects

Renal tubular dysfunction observed in Phase 1 human trial
Dose-dependent nephrotoxicity in animal models
Injection-site irritation
Dehydration risk secondary to renal effects
Early-stage, preclinical to limited human research — safety profile not established

Contraindications

Renal impairment or history of kidney disease
Dehydration
Pregnancy and lactation
Concomitant nephrotoxic medications

Stacking Partners

Peptides commonly paired with Adipotide in published research and protocol write-ups.

glp1

AOD-9604

Lipolytic signaling (preclinical)

other

5-Amino-1MQ

Adipocyte size reduction (preclinical)

Vendor Pricing

75
Swiss Chems
Best $/mg
Size5mg
Total$63.95
/ mg$12.79/mg
In stock
View
70
Certified Peptides
Size10mg
Total$165.00
/ mg$16.50/mg
In stock
View

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Gear + Companions

Reconstitution supplies and research-backed supplement companions for Adipotide. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials

Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
View at Pantheon →
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Buy on Amazon →
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
Buy on Amazon →
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Buy on Amazon →

As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines

Research Papers

Reversal of obesity by targeted ablation of adipose tissue vasculature
Kolonin MG, et al. · Nature Medicine · 2004
PubMed 15133499 →
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys
Barnhart KF, et al. · Science Translational Medicine · 2011
PubMed 22072637 →

Adipotide

Mechanism of Action

Researched Benefits