Mazdutide
IBI362 · LY3305677 · Dual GLP-1/glucagon agonist
Think of it as a metabolic multitasker.
Mazdutide is like a two-in-one tool for your metabolism. Imagine a switch that both curbs your hunger and ramps up your body's energy use. It mimics natural signals that tell your brain you're full and help your body burn through stored energy. This means you might feel less hungry and your body could start tapping into its energy reserves.
It's been primarily studied in people with obesity and type 2 diabetes, showing promising results in shedding pounds and keeping blood sugar levels in check. The idea is that by combining these effects, Mazdutide could offer a comprehensive approach to managing weight and metabolic health, especially for those who have struggled with traditional methods.
Who it's for
- People looking to lose weight when other methods haven't worked.
- Those managing type 2 diabetes and seeking better blood sugar control.
- Individuals curious about cutting-edge metabolic health strategies.
Probably not for you if…
- Anyone uncomfortable with investigational treatments or needles.
- Individuals not struggling with weight or metabolic health issues.
- Those looking for quick fixes without lifestyle changes.
Editorial summary for research context · Not medical advice
Mechanism of Action
Mazdutide is an investigational once-weekly dual agonist of the GLP-1 and glucagon receptors, structurally based on the mammalian peptide oxyntomodulin. GLP-1 activity drives appetite suppression, slowed gastric emptying, and glucose-dependent insulin release; glucagon receptor activity is hypothesized to increase energy expenditure and promote hepatic fat mobilization. Developed by Innovent Biologics in partnership with Eli Lilly, primarily studied in Chinese populations. Investigational — only pharmaceutical-grade product under clinical supervision is appropriate for human use.
Researched Benefits
Weight reduction
GLORY-1 Phase 3 trial in Chinese adults with obesity reported mean weight loss of ~14% at the 6mg weekly dose over 48 weeks.
- [Ji et al. 2024 (GLORY-1)]
Glycemic control
DREAMS-1 Phase 2 trial in type 2 diabetes showed HbA1c reductions of ~1.8 percentage points at higher doses.
- [Ji et al. 2023]
Hepatic fat reduction
Early-phase imaging sub-studies report meaningful reductions in liver fat fraction alongside weight loss.
Research Protocols
The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.
Clinical titration (investigational — prescription required)
- Dosage
- 1.5 mg
- Frequency
- once weekly
- Timing
- same day each week
- Cycle
- 4 weeks
Phase 3 trials titrate 1.5 → 3 → 4.5 → 6mg weekly. Investigational and only approved in China for obesity (2025). Only pharmaceutical-grade product under clinical supervision is appropriate.
Reported Side Effects
- Gastrointestinal: nausea, diarrhea, decreased appetite (titration-related)
- Injection-site reactions
- Transient heart rate elevation
- Potential glucagon-mediated effects on resting metabolic rate
Contraindications
- Personal or family history of medullary thyroid carcinoma
- Multiple Endocrine Neoplasia syndrome type 2
- Pregnancy and lactation
- History of pancreatitis
Stacking Partners
Peptides commonly paired with Mazdutide in published research and protocol write-ups.
Vendor Pricing
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Gear + Companions
Reconstitution supplies and research-backed supplement companions for Mazdutide. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.
Gear you'll need
· Reconstitution + storage essentialsBacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Stacks well with
· Supplement companions — independent evidence, not sponsoredLMNT Electrolyte Drink Mix Variety Pack (30 sticks)
LMNT
GLP-1 agonism suppresses thirst — dehydration + electrolyte drop is the #1 source of the 'GLP-1 flu' complaint. LMNT targets that gap directly.
Psyllium Husk Fiber Capsules (500 ct)
NOW Foods
Constipation is the most-reported GLP-1 side effect. Daily soluble fiber addresses it without blunting the appetite effect.
Whey Protein Isolate 5 lb (Grass-Fed, Unflavored)
NAKED Nutrition
Appetite suppression tanks protein intake if you don't actively defend it — protein powder is the cheapest floor against lean-mass loss.
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Research Papers
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity
Ji L, et al. · Nature Communications · 2023
PubMed 37985770 →