Growth HormoneResearch profile

CJC-1295 with DAC

CJC-1295 DAC · Drug Affinity Complex GRF · DAC:GRF

Think of it as a slow-release booster for your body's growth signals.

CJC-1295 with DAC is like a long-lasting release button for your body's natural growth signals. Normally, these signals come in short bursts, but this compound keeps the growth-promoting effects going for days. It's like having a steady stream of growth signals rather than quick, fleeting messages.

This means that with CJC-1295 with DAC, you don't need to worry about frequent injections. Just one or two times a week, and you're set. It's a bit like switching from a daily task to a weekly one, simplifying your routine if you're tracking growth over a longer period.

Who it's for

Athletes looking for steady support in muscle growth and recovery
Busy professionals who prefer less frequent injection schedules
Biohackers interested in exploring long-term effects of growth hormone elevation

Probably not for you if…

Those who prefer natural, non-synthetic interventions
People uncomfortable with any form of injection
Individuals not interested in manipulating growth hormone levels

Editorial summary for research context · Not medical advice

Mechanism of Action

CJC-1295 with DAC is a modified GHRH(1-29) analog covalently bound to a Drug Affinity Complex (maleimidopropionic acid) that attaches irreversibly to circulating serum albumin. This extends the half-life from minutes to roughly 6-8 days, producing sustained elevation of baseline GH and IGF-1 ('GH bleed') rather than discrete pulses. The compound retains GHRH-receptor agonism on pituitary somatotrophs but disrupts native pulsatility — a trade-off that is debated in research circles.

Researched Benefits

Sustained IGF-1 elevation

Phase 1 clinical work showed dose-dependent increases in mean plasma GH and IGF-1 persisting beyond one week after single subcutaneous administration.

[Teichman et al. 2006]

Reduced injection frequency

Long albumin-bound half-life allows 1-2x weekly dosing in research protocols versus multiple daily injections for short-acting analogs.

Convenience for long-cycle research

Steady-state pharmacology simplifies IGF-1 tracking in longitudinal studies.

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

Weekly research protocol

Dosage: 2000 mcg
Frequency: once weekly
Timing: any time
Cycle: 8 weeks

Research protocols have used 1-2mg subcutaneous weekly. Some split the weekly dose into 2 injections (twice weekly) for smoother IGF-1 curves.

Reported Side Effects

Water retention and mild edema, especially in first weeks
Numbness or tingling in extremities (paresthesia)
Headache and flushing post-injection
Injection-site induration
Potential for insulin sensitivity reduction at sustained elevated IGF-1

Contraindications

Active malignancy
Pregnancy and lactation
Untreated sleep apnea
Diabetic retinopathy or uncontrolled diabetes

Stacking Partners

Peptides commonly paired with CJC-1295 with DAC in published research and protocol write-ups.

growth hormone

Ipamorelin

GH pulse amplification

growth hormone

CJC-1295 (without DAC)

Preserved pulsatility

Vendor Pricing

65
SolXGenix
Best $/mg
Size5mg
Total$60.00
/ mg$12.00/mg
In stock
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74
Purity Peptides
Size5mg
Total$75.59
/ mg$15.12/mg
In stock
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66
Guru Peptides
Size2mg
Total$32.99
/ mg$16.50/mg
In stock
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74
Purity Peptides
Size2mg
Total$35.99
/ mg$18.00/mg
In stock
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76
Perfect Peptides
Size5mg
Total$95.00
/ mg$19.00/mg
In stock
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75
Swiss Chems
Size20mg
Total$431.95
/ mg$21.60/mg
In stock
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75
Swiss Chems
Size2mg
Total$47.95
/ mg$23.98/mg
In stock
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69
Almighty Peptides
Size5mg
Total$129.99
/ mg$26.00/mg
In stock
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Gear + Companions

Reconstitution supplies and research-backed supplement companions for CJC-1295 with DAC. Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials

Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
View at Pantheon →
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Buy on Amazon →
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
Buy on Amazon →
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Buy on Amazon →

Stacks well with

· Supplement companions — independent evidence, not sponsored

Creatine Monohydrate Powder 1kg
BulkSupplements
Creatine + GH-axis peptides increase lean-mass signaling via different pathways (IGF-1 + phosphocreatine replenishment). Most-studied stack in the literature.
Buy on Amazon →
Whey Protein Isolate 5 lb (Grass-Fed, Unflavored)
NAKED Nutrition
Growth-hormone-axis research is substrate-limited — without adequate protein intake the signaling can't translate to tissue.
Buy on Amazon →

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Research Papers

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Teichman SL, et al. · Journal of Clinical Endocrinology & Metabolism · 2006
PubMed 16352683 →

CJC-1295 with DAC

Mechanism of Action