CJC-1295 (without DAC)
Mod GRF 1-29 · Modified GRF(1-29) · tetrasubstituted GRF
Think of it as a short-term boost for your body's growth signals.
CJC-1295 without DAC is like a quick pep talk for your body's growth hormone system. It gives a brief nudge to your natural growth hormone pulses, helping them stay strong without overstaying its welcome. This means you get the benefits of increased growth hormone activity without disrupting your body's usual rhythm.
When teamed up with certain other compounds, it can amplify the effects, like a cheerleader boosting the team's spirit. This combination can lead to more significant growth hormone pulses, which research suggests might support muscle retention and better sleep quality.
Who it's for
- Fitness enthusiasts looking to support muscle maintenance
- Sleep-deprived go-getters interested in better rest
- Biohackers curious about optimizing natural growth signals
Probably not for you if…
- Those seeking a long-lasting growth hormone boost
- People uncomfortable with frequent injections
- Anyone expecting overnight muscle growth
Editorial summary for research context · Not medical advice
Mechanism of Action
CJC-1295 (without DAC) is a tetrasubstituted 30-amino-acid analog of GHRH(1-29) engineered to resist enzymatic degradation. Without the Drug Affinity Complex (DAC), its half-life is roughly 30 minutes, long enough to reinforce a single endogenous GH pulse without flattening the natural pulsatile rhythm. It binds GHRH receptors on somatotrophs to stimulate GH release.
Researched Benefits
Preserved pulsatility
Short half-life (vs DAC version) maintains physiologic GH pulse architecture rather than producing sustained elevation.
- [Teichman et al. 2006]
Synergy with GHRPs
When paired with a ghrelin mimetic (Ipamorelin, GHRP-2/6), research shows multiplicative GH pulse amplitude versus either compound alone.
Body composition & sleep
GH/IGF-1 elevation supports lean-mass retention and slow-wave sleep in research protocols.
Research Protocols
The following dosing ranges have appeared in published research protocols. Presented for informational purposes only, not a recommendation for human use.
CJC-1295 + Ipamorelin (standard research stack)
- Dosage
- 100 mcg
- Frequency
- 2x daily
- Timing
- pre-bed, fasted morning
- Cycle
- 8 weeks
Commonly paired 100mcg CJC-1295 + 200mcg Ipamorelin in same injection.
Reported Side Effects
- Injection-site redness
- Mild water retention
- Transient flushing immediately post-injection
Contraindications
- Active malignancy
- Pregnancy and lactation
- Untreated sleep apnea
Stacking Partners
Peptides commonly paired with CJC-1295 (without DAC) in published research and protocol write-ups.
Vendor Pricing
Stacked earns a commission on purchases via these links. It does not influence our Trust Scores.
Gear + Companions
Reconstitution supplies and research-backed supplement companions for CJC-1295 (without DAC). Editorial picks only, we earn a commission through Amazon on the click, no sponsorship.
Gear you'll need
· Reconstitution + storage essentialsBacteriostatic Water 30mL (0.9% Benzyl Alcohol)
Empower Pharmacy / generic medical supply
Reconstitutes every lyophilized peptide. 28-day viability refrigerated.
Insulin Syringes 31G × 5/16" × 0.5mL (100 count)
EasyTouch
31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.
Alcohol Prep Pads (Sterile, 200 count)
Dynarex
Sterile 70% IPA prep pads — one per vial stopper + one per injection site.
1-Quart Sharps Disposal Container
BD / Becton Dickinson
FDA-cleared sharps container — pharmacies won't accept improvised disposal.
Stacks well with
· Supplement companions, independent evidence, not sponsoredCreatine Monohydrate Powder 1kg
BulkSupplements
Creatine + GH-axis peptides increase lean-mass signaling via different pathways (IGF-1 + phosphocreatine replenishment). Most-studied stack in the literature.
Whey Protein Isolate 5 lb (Grass-Fed, Unflavored)
NAKED Nutrition
Growth-hormone-axis research is substrate-limited — without adequate protein intake the signaling can't translate to tissue.
As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines
Top Videos
Curated from YouTube, refreshed weekly. Stacked doesn't host or endorse external content.
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Research Papers
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295
Teichman SL, et al. · Journal of Clinical Endocrinology & Metabolism · 2006
PubMed 16352683 →
Frequently Asked
- What is CJC-1295 (without DAC)?
- CJC-1295 (without DAC) is a growth hormone studied in laboratory research. This profile covers its researched mechanism of action, study context, reported side-effect profile, and current vendor pricing. For research purposes only; not medical advice.
- Is CJC-1295 (without DAC) legal to buy?
- CJC-1295 (without DAC) is sold strictly for laboratory and research use and is not approved by the FDA for human consumption. Legal status and import rules vary by country and are the buyer's responsibility.
- How much does CJC-1295 (without DAC) cost?
- Compare live $/mg, total price, stock, and each vendor's Stacked Score for CJC-1295 (without DAC) on its price page. Stacked does not sell peptides; it links out to vetted research vendors.