Stacked
Growth HormoneResearch profile

CJC-1295 (without DAC)

Mod GRF 1-29 · Modified GRF(1-29) · tetrasubstituted GRF

Think of it as a short-term boost for your body's growth signals.

CJC-1295 without DAC is like a quick pep talk for your body's growth hormone system. It gives a brief nudge to your natural growth hormone pulses, helping them stay strong without overstaying its welcome. This means you get the benefits of increased growth hormone activity without disrupting your body's usual rhythm.

When teamed up with certain other compounds, it can amplify the effects, like a cheerleader boosting the team's spirit. This combination can lead to more significant growth hormone pulses, which research suggests might support muscle retention and better sleep quality.

Who it's for

  • Fitness enthusiasts looking to support muscle maintenance
  • Sleep-deprived go-getters interested in better rest
  • Biohackers curious about optimizing natural growth signals

Probably not for you if…

  • Those seeking a long-lasting growth hormone boost
  • People uncomfortable with frequent injections
  • Anyone expecting overnight muscle growth

Editorial summary for research context · Not medical advice

Mechanism of Action

CJC-1295 (without DAC) is a tetrasubstituted 30-amino-acid analog of GHRH(1-29) engineered to resist enzymatic degradation. Without the Drug Affinity Complex (DAC), its half-life is roughly 30 minutes — long enough to reinforce a single endogenous GH pulse without flattening the natural pulsatile rhythm. It binds GHRH receptors on somatotrophs to stimulate GH release.

Researched Benefits

Preserved pulsatility

Short half-life (vs DAC version) maintains physiologic GH pulse architecture rather than producing sustained elevation.

  • [Teichman et al. 2006]

Synergy with GHRPs

When paired with a ghrelin mimetic (Ipamorelin, GHRP-2/6), research shows multiplicative GH pulse amplitude versus either compound alone.

Body composition & sleep

GH/IGF-1 elevation supports lean-mass retention and slow-wave sleep in research protocols.

Research Protocols

The following dosing ranges have appeared in published research protocols. Presented for informational purposes only — not a recommendation for human use.

CJC-1295 + Ipamorelin (standard research stack)

Dosage
100 mcg
Frequency
2x daily
Timing
pre-bed, fasted morning
Cycle
8 weeks

Commonly paired 100mcg CJC-1295 + 200mcg Ipamorelin in same injection.

Reported Side Effects

  • Injection-site redness
  • Mild water retention
  • Transient flushing immediately post-injection

Contraindications

  • Active malignancy
  • Pregnancy and lactation
  • Untreated sleep apnea

Stacking Partners

Peptides commonly paired with CJC-1295 (without DAC) in published research and protocol write-ups.

growth hormone

Ipamorelin

GH pulse amplification

growth hormone

GHRP-2 Acetate

Potent GH release

Vendor Pricing

Stacked earns a commission on purchases via these links. It does not influence our Trust Scores.

Gear + Companions

Reconstitution supplies and research-backed supplement companions for CJC-1295 (without DAC). Editorial picks only — we earn a commission through Amazon on the click, no sponsorship.

Gear you'll need

· Reconstitution + storage essentials

  • Bacteriostatic Water 30mL (0.9% Benzyl Alcohol)

    Empower Pharmacy / generic medical supply

    Reconstitutes every lyophilized peptide. 28-day viability refrigerated.

    View at Pantheon →

  • Insulin Syringes 31G × 5/16" × 0.5mL (100 count)

    EasyTouch

    31G × 0.5mL insulin syringes — the default size for sub-0.25mL peptide doses.

    Buy on Amazon →

  • Alcohol Prep Pads (Sterile, 200 count)

    Dynarex

    Sterile 70% IPA prep pads — one per vial stopper + one per injection site.

    Buy on Amazon →

  • 1-Quart Sharps Disposal Container

    BD / Becton Dickinson

    FDA-cleared sharps container — pharmacies won't accept improvised disposal.

    Buy on Amazon →

Stacks well with

· Supplement companions — independent evidence, not sponsored

  • Creatine Monohydrate Powder 1kg

    BulkSupplements

    Creatine + GH-axis peptides increase lean-mass signaling via different pathways (IGF-1 + phosphocreatine replenishment). Most-studied stack in the literature.

    Buy on Amazon →

  • Whey Protein Isolate 5 lb (Grass-Fed, Unflavored)

    NAKED Nutrition

    Growth-hormone-axis research is substrate-limited — without adequate protein intake the signaling can't translate to tissue.

    Buy on Amazon →

As an Amazon Associate we earn from qualifying purchases · Disclosed per FTC guidelines

Top Videos

Curated from YouTube — refreshed weekly. Stacked doesn't host or endorse external content.

Thumbnail for The Strongest Peptide for Building Muscle | CJC 1295 & Ipamorelin Benefits & Risks14:34

The Strongest Peptide for Building Muscle | CJC 1295 & Ipamorelin Benefits & Risks

Thomas DeLauer

355.7K views · 14:34 · 1 year ago

Thumbnail for Doctor Explains Your RISK of Cancer From Popular Peptides7:15

Doctor Explains Your RISK of Cancer From Popular Peptides

This Is Not Covered - Dr. Ashley Froese

173.1K views · 7:15 · 5 months ago

Thumbnail for Insights and Risks with CJC-1295 Ipamorelin9:38

Insights and Risks with CJC-1295 Ipamorelin

Regan Archibald

94.7K views · 9:38 · 6 months ago

Thumbnail for Real Dr Explains CJC-1295 + Ipamorelin - The CLASSIC Peptide Stack10:40

Real Dr Explains CJC-1295 + Ipamorelin - The CLASSIC Peptide Stack

This Is Not Covered - Dr. Ashley Froese

93.3K views · 10:40 · 1 month ago

Thumbnail for Peptide Journey Update - End of Week 7 (CJC1295/Ipamorelin)4:01

Peptide Journey Update - End of Week 7 (CJC1295/Ipamorelin)

Fizzness Shizzness

89.9K views · 4:01 · 3 years ago

Research Papers

  • Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295

    Teichman SL, et al. · Journal of Clinical Endocrinology & Metabolism · 2006

    PubMed 16352683 →